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Title: The effects of different ventilatory modes in female adult rats submitted to mechanical ventilation.
Authors: Almeida, Matheus Rocha
Horta, Jacques Gabriel Álvares
Matos, Natália Alves de
Souza, Ana Beatriz Farias de
Castro, Thalles de Freitas
Cândido, Leandro da Silva
Andrade, Mônica Campos
Cangussú, Silvia Dantas
Costa, Guilherme de Paula
Silva, André Talvani Pedrosa da
Bezerra, Frank Silva
Keywords: Inflammation
Issue Date: 2021
Citation: ALMEIDA, M. R. et al. The effects of different ventilatory modes in female adult rats submitted to mechanical ventilation. Respiratory Physiology & Neurobiology, v. 284, id 103583, 2021. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: This study aimed to analyze the effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) modes in female Wistar rats. 18 Wistar female adult rats were divided into three groups: control (CG), pressure-controlled ventilation (PCVG), and volume-controlled ventilation (VCVG). PCVG and VCVG were submitted to MV for one hour with a tidal volume (TV) of 8 mL/Kg, respiratory rate of 80 breaths/min, and positive end-expiratory pressure of 0 cmH2O. At the end of the experiment, all animals were euthanized. The neutrophils and lymphocytes influx to lung were higher in VCVG and PCVG compared to CG. The activities of superoxide dismutase, catalase and myeloperoxidase were higher in PCVG compared to CG. There was an increase in lipid peroxidation and protein oxidation in PCVG compared to CG. The levels of CCL3 and CCL5 were higher in PCVG compared to CG. In conclusions, the PCV mode promoted structural changes in the lung parenchyma, redox imbalance and inflammation in healthy adult female rats submitted to MV.
ISSN: 1569-9048
Appears in Collections:DECBI - Artigos publicados em periódicos

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