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Title: Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo : an intravital microscopic study.
Authors: Queiroz, Norinne Lacerda
Lima, Onésia Cristina Oliveira
Carneiro, Cláudia Martins
Vilela, Márcia de Carvalho
Teixeira, Antônio Lúcio
Carvalho, Andréa Teixeira de
Araújo, Márcio Sobreira Silva
Martins Filho, Olindo Assis
Braga, Érika Martins
Tavares, Juliana Carvalho
Keywords: Experimental malaria
Intravital microscopy
Cerebral inflammation
Issue Date: 2011
Citation: QUEIROZ, N. L. et al. Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo : an intravital microscopic study. Acta Tropica, v. 120, n.1–2, p. 31–39, out./nov. 2011. Disponível em: <>. Acesso em: 11 set. 2012.
Abstract: Malaria is second only to tuberculosis as the leading cause of morbidity and mortality as a consequence of a single infectious agent. Much of the pathology of malaria arises from the inappropriate or excessive immune response mounted by the host in an attempt to eliminate the parasite. We here report the inflammatory changes observed in the cerebral microvasculature of C57BL/6 and BALB/c mice that had been inoculated with Plasmodium berghei NK65, a lethal strain of rodent malaria. Although no neurological signs were observed in experimentally infected mice, inflammation of the cerebral microvasculature was clearly evident. Histopathological analysis demonstrated that alterations in cerebral tissue were more intense in infected C57Bl/6 mice than in infected BALB/c animals. Intravital microscopic examination of the cerebral microvasculature revealed increased leukocyte rolling and adhesion in pial venules of infected mice compared with non-infected animals. The extravasation of Evans blue dye into the cerebral parenchyma was also elevated in infected mice in comparison with their non-infected counterparts. Additionally, protein levels of TNF-_, MIG/CXCL9, MCP-1/CCL2, MIP-1_/CCL3 and RANTES/CCL5 were up-regulated in brain samples derived from infected C57Bl/6 mice. Taken together, the data reported here illustrate the complex strain-dependent relationships between leukocyte recruitment, blood brain barrier permeability and chemokine production.
ISSN: 0001706X
metadata.dc.rights.license: O periódico Acta Tropical concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280860842544.
Appears in Collections:DEACL - Artigos publicados em periódicos

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