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Title: Protective effects of quercetin on livers from mice exposed to long-term cigarette smoke.
Authors: Machado Júnior, Pedro Alves
Araújo, Natália Pereira da Silva
Souza, Ana Beatriz Farias de
Castro, Thalles de Freitas
Oliveira, Michel Ângelo das Graças Silva
Costa, Guilherme de Paula
Matos, Natália Alves de
Vieira, Paula Melo de Abreu
Silva, André Talvani Pedrosa da
Bezerra, Frank Silva
Cangussú, Silvia Dantas
Issue Date: 2020
Citation: MACHADO JÚNIOR, P. A. et al. Protective effects of quercetin on livers from mice exposed to long-term cigarette smoke. Biomed Research International, v. 2020, article ID 2196207, nov. 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.
ISSN:  2314-6141
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o PDF do artigo.
Appears in Collections:DECBI - Artigos publicados em periódicos

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