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http://www.repositorio.ufop.br/jspui/handle/123456789/13756
Title: | Açaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis. |
Authors: | Magalhães, Talita Alves Faria Martins Souza, Melina Oliveira de Gomes, Sttefany Viana Silva, Raiana Mendes e Martins, Flaviano dos Santos Freitas, Renata Nascimento de Amaral, Joana Ferreira do |
Issue Date: | 2020 |
Citation: | MAGALHÃES, T. A. F. M. et al. Açaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis. Nutrition and Cancer, v. 73, n. 3, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/01635581.2020.1759659>. Acesso em: 10 jun. 2021. |
Abstract: | Intestinal mucositis (IM) caused by antineoplastic chemotherapy is characterized by an important inflammatory process, which may compromise ongoing treatment. Our study aimed to investigate the effect of Ac¸aı (Euterpe oleracea Martius) on the antioxidant response in BALB/c mice pretreated with Ac¸aı pulp (200 g/kg) for 14 day. A group of animals receiving a single intraperitoneal injection of 5-FU (200 mg/kg) were euthanized on day three (D3) or seven (D7) after administration, the distal jejunum was isolated for the analyses of histology, superoxide dismutase (SOD) and catalase (CAT) enzyme activities, and concentration of total sulfhydryl groups (GSH). Seven days after induction, the intake of Ac¸aı by the IM group almost completely regenerated tissue histology. Notably, SOD activity decreased in the MUC þ Ac¸aı group (D3). CAT activity reduced on D3 and D7 in the IM groups and Ac¸aı treatment groups, respectively. No change was observed in the total GSH concentration at the tissue level. Our results demonstrated the protective effect of Ac¸aı pulp components on intestinal damage induced by 5-FU, as well as the ability to control the response to oxidative stress, in order to mobilize defense pathways and promote tissue repair. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/13756 |
metadata.dc.identifier.uri2: | https://www.tandfonline.com/doi/abs/10.1080/01635581.2020.1759659 |
metadata.dc.identifier.doi: | https://doi.org/10.1080/01635581.2020.1759659 |
ISSN: | 1532-7914 |
Appears in Collections: | DEALI - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_AçaiEuterpeOleracea.pdf Restricted Access | 2,22 MB | Adobe PDF | View/Open |
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