Please use this identifier to cite or link to this item:
http://www.repositorio.ufop.br/jspui/handle/123456789/13698| Title: | Cytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts. |
| Authors: | Pereira, Deise Inocêncio Amparo, Tatiane Roquete Almeida, Tamires Cunha Costa, Fernanda Senna Ferreira Brandão, Geraldo Célio Santos, Orlando David Henrique dos Silva, Glenda Nicioli da Souza, Gustavo Henrique Bianco de |
| Keywords: | Flavonoids Polymeric micelles Pluronic |
| Issue Date: | 2020 |
| Citation: | PEREIRA, D. I. et al. Cytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts. Natural Product Research, nov. 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1851220?journalCode=gnpl20>. Acesso em: 10 jun. 2021. |
| Abstract: | Bladder cancer has a high incidence and recurrence rate among patients worldwide. This study aimed to evaluate the cytotoxic activity of fractions of Sambucus nigra L. flower extracts on bladder carcinoma cells (T24 cells) and human fibroblast cells (MRC-5). The butanolic fraction (F-BuOH) was characterized by UPLC-DADMS/MS and nine flavonoids were identified. Rutin was the major compound. The cytotoxic activity of this fraction was observed in the T24 cells but not in MRC-5 cells, indicating selectivity. F-BuOH was incorporated in micellar solutions of PluronicVR F127 and cytotoxic effect for T24 cells was observed again. In vitro assay demonstrated a controlled release of the fraction from the micelles. The results obtained showed that flavonoids are the possible responsible for cytotoxic activity in bladder carcinoma cells. In addition, micellar solutions act together to increase the action of the butanolic fraction. |
| URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/13698 |
| metadata.dc.identifier.uri2: | https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1851220?journalCode=gnpl20 |
| metadata.dc.identifier.doi: | https://doi.org/10.1080/14786419.2020.1851220 |
| ISSN: | 1478-6427 |
| Appears in Collections: | DEACL - Artigos publicados em periódicos |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_CytotoxicActivityButanolic.pdf Restricted Access | 910,17 kB | Adobe PDF | View/Open |
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