Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/13680
Title: Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions.
Authors: Silva, Nayara Nascimento Toledo
Santos, Ana Carolina da Silva
Carneiro, Cláudia Martins
Lima, Angélica Alves
Keywords: HPV
Issue Date: 2020
Citation: SILVA, N. N. T. et al. Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions. Clinical Nutrition ESPEN, v. 38, p. 223-228, 2020. Disponível em: <https://clinicalnutritionespen.com/article/S2405-4577(20)30077-2/fulltext>. Acesso em: 10 jun. 2021.
Abstract: Background & aims: Diet and lifestyle play an important role in etiology of various tumors. Serum concentration of folate and vitamin B12may be associated with carcinogenesis since they are involved in DNA methylation and nucleotide synthesis. However, the role of these micronutrients on development of cervical cancer is still controversial. Thus, the aim of this study was to analyze the association of lower status of folate and vitamin B12 with the risk of pre-neoplastic cervical lesions. Methods: Our sample group was divided in Control group (n ¼ 120) - women with normal cytology, and Case groups (n ¼ 57) e women presenting Atypical Squamous Cells of Undetermined Significance (ASCUS, n ¼ 21), Low Grade Squamous Intraepithelial Lesion (LSIL; n ¼ 16), and High-Grade lesions (n ¼ 20). We obtained cervical samples for cytology analysis and HPV detection, and blood samples for evaluation of serum concentration of folate and vitamin B12. Results: No difference of serum folate was observed among Cases and Control groups. On the other hand, women with High-Grade lesions presented significant lower median concentration of vitamin B12 if compared to another groups. Then, we observed increased risk of High-Grade lesions among participants with low vitamin B12 levels was observed in relation to women that presented high levels of the micronutrient and from Control group [OR (95% CI): 2.09 (0.65e6.76), p ¼ 0.216], ASC-US [OR (95% CI): 3.15 (0.82e12.08), p ¼ 0.095], and LSIL [OR (95% CI): 3.10 (0.76e12.70), p ¼ 0.116]. Conclusions: Low concentration of vitamin B12 was associated with an increased risk of High-Grade cervical lesions. Besides, we did not observe any difference of serum folate among women with normal cytology and women with pre-neoplastic cervical lesions.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/13680
metadata.dc.identifier.uri2: https://clinicalnutritionespen.com/article/S2405-4577(20)30077-2/fulltext
metadata.dc.identifier.doi: https://doi.org/10.1016/j.clnesp.2020.04.007
ISSN: 2405-4577
Appears in Collections:DEACL - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_AssociationSerumFolate.pdf
  Restricted Access
264,09 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.