Please use this identifier to cite or link to this item:
Title: Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian Arnica).
Authors: Oliveira, Patricia Capelari de
Paula, Carmem Aparecida de
Rezende, Simone Aparecida
Campos, Fernanda Torres
Guimarães, Andrea Grabe
Lombardi, Júlio Antônio
Guimarães, Dênia Antunes Saúde
Keywords: Paw oedema
Lychnophora passerina
Issue Date: 2011
Citation: OLIVEIRA, P. C. de et al. Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian Arnica ). Journal of Ethnopharmacology, v. 135, n.2, p.393-398, mai. 2011. Disponível em: <>. Acesso em: 13 ago. 2012.
Abstract: Ethnopharmacological relevance: Lychnophorapasserina (Asteraceae), popularly known as “arnica,” is used to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine. Materials and methods: The anti-inflammatoryactivity of crude ethanolic extract of aerial parts of L. passerina and its ethyl acetate and methanolic fractions had their abilities to modulate the production of NO, TNF-α and IL-10 inflammatory mediators in LPS/IFN-γ-stimulated J774.A1 macrophages evaluated. Moreover, the crude ethanolic extract and derived fractions were also in vivo assayed by carrageenan-induced paw oedema in mice. Results: In vitro assays showed remarkable anti-inflammatoryactivity of L. passerina crude ethanolic extract (EE) and its ethyl acetate (A) and methanolic (M) fractions, through the inhibition of production of NO and TNF-α inflammatory mediators and induction of production of IL-10 anti-inflammatory cytokine. In vivo assays showed anti-inflammatoryactivity for EE 10% ointment, similar to the standard drug diclofenac gel. The A and M fraction ointments 20% presented anti-inflammatoryactivity. Conclusion: The results obtained showed that possible anti-inflammatory effects of EE and its A and M fractions may be attributed to inhibition pro-inflammatory cytokines production, TNF-α and NO and to increased IL-10 production. EE, A and M ointments showed topical in vivoanti-inflammatoryactivity. The in vivoanti-inflammatoryactivity of EE of L. passerina may be related to synergistic effects of different substances in the crude extract. Therefore, traditional use of aerial parts of L. passerina in the inflammatory conditions could be beneficial to treat topical inflammatory conditions, as evidenced by the present study.
ISSN: 03788741
metadata.dc.rights.license: O Periódico Journal of Ethnopharmacology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 500790586.
Appears in Collections:DEFAR - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_AntiInflammatoryActivity.pdf749,38 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.