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dc.contributor.authorSouza, Maíra Ribeiro de-
dc.contributor.authorPaula, Carmem Aparecida de-
dc.contributor.authorResende, Michelle Luciane Pereira de-
dc.contributor.authorGuimarães, Andrea Grabe-
dc.contributor.authorSouza Filho, José Dias de-
dc.contributor.authorGuimarães, Dênia Antunes Saúde-
dc.identifier.citationSOUZA, M. R. de et al. Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis : anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. Journal of Ethnopharmacology, v. 142, n.3, p.845-850, ago. 2012. Disponível em: <>. Acesso em: 13 ago. 2012.pt_BR
dc.description.abstractEthnopharmacological relevance: The ethanolic extract of Lychnophoratrichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. Aim of the study: The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation. Materials and methods: L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated. Results: Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250 mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice. Conclusions: Ethanolic extract of Lychnophoratrichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties.pt_BR
dc.subjectXanthine oxidasept_BR
dc.subjectLychnophora trichocarphapt_BR
dc.titlePharmacological basis for use of Lychnophora trichocarpha in gouty arthritis : anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO Periódico Journal of Ethnopharmacology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 500790586-
Appears in Collections:DEFAR - Artigos publicados em periódicos

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