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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Silva, Ivair Ramos | - |
dc.contributor.author | Lingling, Li | - |
dc.contributor.author | Kulldorff, Martin | - |
dc.date.accessioned | 2020-08-17T14:07:00Z | - |
dc.date.available | 2020-08-17T14:07:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | SILVA, I. R.; LINGLING, L.; KULLDORFF, M. Exact conditional maximized sequential probability ratio test adjusted for covariates. Sequential Analysis-Design Methods and Applications, v. 38, n. 1, p. 115-133, maio 2019. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/07474946.2019.1574446?journalCode=lsqa20>. Acesso em: 03 jul. 2020. | pt_BR |
dc.identifier.issn | 1532-4176 | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/12604 | - |
dc.description.abstract | Sequential analysis is now commonly used for post-market drug and vaccine safety surveillance, and a Poisson stochastic process is typically used for rare adverse events. The conditional maximized sequential probability ratio test, CMaxSPRT, is a powerful tool when there is uncertainty in the estimated expected counts under the null hypothesis. This paper derives exact critical values for CMaxSPRT, as well as statistical power and expected time to signal. This is done for both continuous and group sequential analysis, and for different rejection boundaries. It is also shown how to adjust for covariates in the sequential design. A table of critical values is provided for selected parameters and rejection boundaries, while new functions in the R Sequential package can be used for other calculations. In addition, the method is illustrated for monitoring adverse events after pediarix vaccination data. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Maximized sequential probability ratio test (MaxSPRT) | pt_BR |
dc.subject | Poisson distribution | pt_BR |
dc.subject | Type I error spending | pt_BR |
dc.title | Exact conditional maximized sequential probability ratio test adjusted for covariates. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.identifier.uri2 | https://www.tandfonline.com/doi/abs/10.1080/07474946.2019.1574446?journalCode=lsqa20 | pt_BR |
dc.identifier.doi | https://doi.org/10.1080/07474946.2019.1574446 | pt_BR |
Aparece nas coleções: | DEEST - Artigos publicados em periódicos |
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ARTIGO_ExactConditionalMaximized.pdf Restricted Access | 1,63 MB | Adobe PDF | Visualizar/Abrir |
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