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Title: Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material.
Authors: Santos, Stefânia Sales de Oliveira
Millán, Ruben Dario Sinisterra
Speziali, Marcelo Gomes
Keywords: Weibull kinetic model
Korsmeyer – peppas kinetic model
Issue Date: 2020
Citation: SANTOS, S. S. O.; MILLÁN, R. D. S.; SPEZIALI, M. G. Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material. European Polymer Journal, v. 124, n. 109490, fev. 2020. Disponível em: <>. Acesso em: 10 fev. 2020.
Abstract: This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.
ISSN: 0014-3057
Appears in Collections:DEQUI - Artigos publicados em periódicos

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