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Título: | Bioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil. |
Autor(es): | Gontijo, Douglas da Costa Leite, João Paulo Viana Nascimento, Maria Fernanda Alves do Brandão, Geraldo Célio Oliveira, Alaíde Braga de |
Palavras-chave: | Malaria Chemotaxonomic survey Plasmodium falciparum Phytochemical analysis Bioactive extracts |
Data do documento: | 2019 |
Referência: | GONTIJIO, D. C. et al. Bioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil. Natural Product Research, jun. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1633645>. Acesso em: 10 fev. 2020. |
Resumo: | A total of 33 extracts of eleven different plants species from Mata Atlântica biome, Brazil, and different fractions of the bioactive extracts were evaluated against chloroquine-resistant Plasmodium falciparum W2 strain by PfLDH method and cytotoxicity to HepG2 cells by the MTT assay, and chemically characterized by LC-DAD-ESI-MS/MS analysis. The results allowed the identification of Alchornea glandulosa, Miconia latecrenata, and Psychotria suterella as the most active plant species. Different flavonoids and tannins in Alchornea glandulosa and Miconia latecrenata besides alkaloids in Psychotria suterella were identified. Bioguided fractionation of A. glandulosa and M. latecrenata leaves extracts led to fractions exhibiting high parasite growth inhibition. Seven known alkaloids were identified in the P. suterella extract, and of these, only 5-carboxystrictosidine had been assayed for antiplasmodial activity what points to this species as the most promising among the eleven one assayed. |
URI: | http://www.repositorio.ufop.br/handle/123456789/12201 |
Link para o artigo: | https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1633645 |
DOI: | https://doi.org/10.1080/14786419.2019.1633645 |
ISSN: | 1478-6427 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_BioprospectionAntiplamodialActivity.pdf Restricted Access | 1,15 MB | Adobe PDF | Visualizar/Abrir |
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