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dc.contributor.authorCorrêa, Daniel Henrique do Amaral-
dc.contributor.authorMelo, Patrícia Silva-
dc.contributor.authorCarvalho, Carlos Alberto Alves de-
dc.contributor.authorAzevedo, Mariângela de Burgos Martins de-
dc.contributor.authorDurán, Nelson-
dc.contributor.authorHaun, Marcela-
dc.identifier.citationCORRÊA, D. H. A. et al. Dehydrocrotonin and its h-cyclodextrin complex : Cytotoxicity in V79 fibroblasts and rat cultured hepatocytes. European Journal of Pharmacology, v. 510, n. 1-2, p. 17-24, mar. 2005. Disponível em: <>. Acesso em: 01 ago. 2012.pt_BR
dc.description.abstractTrans-dehydrocrotonin has antiulcerogenic and antitumor activities. A complex of h-cyclodextrin with dehydrocrotonin was developed to improve the delivery of dehydrocrotonin. Complex in solid state was evaluated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). X-ray diffraction and scanning electron microscopy studies showed that dehydrocrotonin exists in a semicrystalline state in the complexed form with h-cyclodextrin. Differential scanning calorimetry studies showed the existence of a complex of dehydrocrotonin with h-cyclodextrin. The thermal gravimetric analysis studies confirmed the differential scanning calorimetry results of the complex. Free dehydrocrotonin and the dehydrocrotonin/h-cyclodextrin inclusion complex were assayed in freshly isolated rat hepatocytes and in V79 cells. Cytotoxicity was determined using nucleic acid content, methylthiazoletetrazolium (MTT) reduction and neutral red uptake assays. In all assays, there was a large reduction (3.5–16.1-fold) in the cytotoxicity of dehydrocrotonin in hepatocytes when complexed with h-cyclodextrin, whereas for V79 cells the decrease in cytotoxicity was 1.7- and 1.87-fold for MTT reduction and nucleic acid content assays, respectively. The lower cytotoxicity of the dehydrocrotonin/hcyclodextrin complex compared to free dehydrocrotonin in rat hepatocytes and V79 cells suggests that such a complex may be useful for the administration of dehydrocrotonin in vivo.pt_BR
dc.titleDehydrocrotonin and its h-cyclodextrin complex : Cytotoxicity in V79 fibroblasts and rat cultured hepatocytes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico European Journal of Pharmacology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença 3333160452208.-
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