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Título : | ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. |
Autor : | Lucas Filho, Milton Dayrell Silva, Grazielle Caroline da Côrtes, Steyner de França Guia, Thiago Rennó dos Mares Ferraz, Vany Perpetua Serra, Carla Penido Braga, Fernão Castro |
Palabras clave : | Astilbin Erythroxylum gonocladum In vitro angiotensin converting enzyme inhibitory activity |
Fecha de publicación : | 2010 |
Citación : | LUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711309002372>. Acesso em: 30 jul. 2012. |
Resumen : | Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration. |
URI : | http://www.repositorio.ufop.br/handle/123456789/1214 |
ISSN : | 09447113 |
metadata.dc.rights.license: | O periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180657438. |
Aparece en las colecciones: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_AceInhibitionAstilbin.pdf | 223,34 kB | Adobe PDF | Visualizar/Abrir |
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