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Title: ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.
Authors: Lucas Filho, Milton Dayrell
Silva, Grazielle Caroline da
Côrtes, Steyner de França
Guia, Thiago Rennó dos Mares
Ferraz, Vany Perpetua
Serra, Carla Penido
Braga, Fernão Castro
Keywords: Astilbin
Erythroxylum gonocladum
In vitro angiotensin converting enzyme inhibitory activity
Issue Date: 2010
Citation: LUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <>. Acesso em: 30 jul. 2012.
Abstract: Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.
ISSN: 09447113
metadata.dc.rights.license: O periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180657438.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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