Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/12023
Title: Efects of açai on oxidative stress, ER stress, and infammationrelated parameters in mice with high fat diet-fed induced NAFLD.
Authors: Carvalho, Mayara Medeiros de Freitas
Lage, Nara Nunes
Paulino, Alice Helena de Souza
Pereira, Renata Rebeca
Almeida, Letícia Trindade
Silva, Tales Fernando da
Magalhães, Cíntia Lopes de Brito
Lima, Wanderson Geraldo de
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Guerra, Joyce Ferreira da Costa
Issue Date: 2019
Citation: CARVALHO, M. M. F. et al. Efects of açai on oxidative stress, ER stress, and infammationrelated parameters in mice with high fat diet-fed induced NAFLD. Scientific Reports, v. 9, p. 1-10, maio 2019. Disponível em: <https://www.nature.com/articles/s41598-019-44563-y>. Acesso em: 10 fev. 2020
Abstract: Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactorial, several intracellular events leading to its progression have been identified, including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and altered endoplasmic reticulum (ER) homeostasis. Phenolic compounds, such as those present in açai (Euterpe oleracea Mart.), are considered promising therapeutic agents due to their possible beneficial effects on the prevention and treatment of NAFLD. We tested in vitro effects of aqueous açai extract (AAE) in HepG2 cells and its influence on oxidative stress, endoplasmic reticulum stress, and inflammation in a murine model of high fat diet-induced NAFLD. In vitro AAE exhibited high antioxidant capacity, high potential to inhibit reactive oxygen species production, and no cytotoxicity. In vivo, AAE administration (3 g/kg) for six weeks attenuated liver damage (alanine aminotransferase levels), inflammatory process (number of inflammatory cells and serum TNFα), and oxidative stress, through the reduction of lipid peroxidation and carbonylation of proteins determined by OxyBlot and modulation of the antioxidant enzymes: glutathione reductase, SOD and catalase. No change was observed in collagen content indicating an absence of fibrosis, stress-related genes in RE, and protein expression of caspase-3, a marker of apoptosis. With these results, we provide evidence that açai exhibits hepatoprotective effects and may prevent the progression of liver damage related to NAFLD by targeting pathways involved in its progression.
URI: http://www.repositorio.ufop.br/handle/123456789/12023
metadata.dc.identifier.doi: https://doi.org/10.1038/s41598-019-44563-y
ISSN: 2045-2322
metadata.dc.rights.license: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o próprio artigo.
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