Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11993
Title: Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats.
Authors: Sousa, Luiz Eduardo de
Favero, Iuri Ferrari Del
Bezerra, Frank Silva
Souza, Ana Beatriz Farias de
Alzamora, Andréia Carvalho
Keywords: Oxidative stress
Issue Date: 2019
Citation: SOUZA, L. E. et al. Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. Arquivos Brasileiros de Cardiologia, v. 113, n. 5, p. 905-912, 2019. Disponível em: <http://www.scielo.br/scielo.php?pid=S0066-782X2019001100905&script=sci_arttext>. Acesso em: 10 fev. 2020.
Abstract: Background: Arterial hypertension is a precursor to the development of heart and renal failure, furthermore is associated with elevated oxidative markers. Environmental enrichment of rodents increases performance in memory tasks, also appears to exert an antioxidant effect in the hippocampus of normotensive rats. Objectives: Evaluate the effect of environmental enrichment on oxidative stress in the ventrolateral medulla, heart, and kidneys of renovascular hypertensive rats. Methods: Forty male Fischer rats (6 weeks old) were divided into four groups: normotensive standard condition (Sham‑St), normotensive enriched environment (Sham-EE), hypertensive standard condition (2K1C-St), and hypertensive enriched environment (2K1C-EE). Animals were kept in enriched or standard cages for four weeks after all animals were euthanized. The level of significance was at p < 0.05. Results: 2K1C-St group presented higher mean arterial pressure (mmHg) 147.0 (122.0; 187.0) compared to Sham-St 101.0 (94.0; 109.0) and Sham-EE 106.0 (90.8; 117.8). Ventrolateral medulla from 2K1C-EE had higher superoxide dismutase (SOD) (49.1 ± 7.9 U/mg ptn) and catalase activity (0.8 ± 0.4 U/mg ptn) compared to SOD (24.1 ± 9.8 U/mg ptn) and catalase activity (0.3 ± 0.1 U/mg ptn) in 2K1C-St. 2K1C-EE presented lower lipid oxidation (0.39 ± 0.06 nmol/mg ptn) than 2K1C-St (0.53 ± 0.22 nmol/mg ptn) in ventrolateral medulla. Furthermore, the kidneys of 2K1C-EE (11.9 ± 2.3 U/mg ptn) animals presented higher superoxide-dismutase activity than those of 2K1C-St animals (9.1 ± 2.3 U/mg ptn). Conclusion: Environmental enrichment induced an antioxidant effect in the ventrolateral medulla and kidneys that contributes to reducing oxidative damage among hypertensive rats. (Arq Bras Cardiol. 2019; 113(5):905-912).
URI: http://www.repositorio.ufop.br/handle/123456789/11993
metadata.dc.identifier.doi: http://dx.doi.org/10.5935/abc.20190166
ISSN: 1678-4170
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o próprio artigo.
Appears in Collections:DECBI - Artigos publicados em periódicos

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