Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11965
Title: Lifetime overproduction of circulating angiotensin‑(1‑7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise.
Authors: Oliveira, Lenice Kappes Becker
Totou, Nádia Lúcia
Oliveira, Mariana Flávia
Coelho, Daniel Barbosa
Oliveira, Emerson Cruz de
Santos, Daisy Motta
Garcia, Emerson Silami
Santos, Maria José Campagnole dos
Santos, Robson Augusto Souza dos
Keywords: Glucose metabolism
Issue Date: 2019
Citation: BECKER, L. K. et al. Lifetime overproduction of circulating angiotensin‑(1‑7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise. Chinese Journal of Physiology, v. 62, n. 5, p. 226-230, set./out. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/09603123.2019.1597833>. Acesso em: 10 fev. 2020.
Abstract: Angiotensin‑(1‑7) (Ang‑[1‑7]) can modulate glucose metabolism and protect against muscular damage. The aim of this study was to investigate the influence of lifetime increase of circulating levels of Ang‑(1‑7) at exhaustive swimming exercise (ESE). Sprague‑Dawley (SD) and transgenic rats TGR(A1‑7)3292 (TR) which overproduce Ang‑(1‑7) (2.5‑fold increase) were submitted to ESE. The data showed no differences in time to exhaustion (SD: 4.90 ± 1.37 h vs. TR: 5.15 ± 1.15 h), creatine kinase, and transforming growth factor beta (TGF-β). Lactate dehydrogenase (SD: 219.9 ± 12.04 U/L vs. TR: 143.9 ± 35.21 U/L) and α‑actinin (SD: 336.7 ± 104.5 U/L vs. TR: 224.6 ± 82.45 U/L) values were significantly lower in TR. There was a significant decrease in the range of blood glucose levels (SD: −41.4 ± 28.32 mg/dl vs. TR: −13.08 ± 39.63 mg/dl) in SD rats. Muscle (SD: 0.06 ± 0.02 mg/g vs. TR: 0.13 ± 0.01 mg/g) and hepatic glycogen (SD: 0.66 ± 0.36 mg/g vs. TG: 2.24 ± 1.85 mg/g) in TR were higher. The TR presented attenuation of the increase in skeletal muscle damage biomarkers and of the changes in glucose metabolism after ESE.
URI: http://www.repositorio.ufop.br/handle/123456789/11965
metadata.dc.identifier.doi: https://doi.org/10.4103/CJP.CJP_57_19
ISSN: 3044-920
metadata.dc.rights.license: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Fonte: o próprio artigo.
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