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Title: Kinin receptors mediating the effect of bradykinin on gastric acid secretion.
Authors: Alzamora, Andréia Carvalho
Ferreira, Patrícia Maria
Oliveira, César Nonato de
Alzamora, Fernando
Vieira, Maria Aparecida Ribeiro
Keywords: Kinin antagonist
Kinin analogues
Gastric mucosa
Carboxipeptidase inhibition
Issue Date: 1998
Citation: ALZAMORA, A. C. et al. Kinin receptors mediating the effect of bradykinin on gastric acid secretion. Reguladory Peptides, v. 73, n. 2, p. 113-117, fev. 1998. Disponível em: <>. Acesso em: 19 jul. 2012.
Abstract: Kinins, and bradykinin in particular, can affect electrolyte transport in different segments of the intestine, thus being able to stimulate chloride secretion. Since the stomach is the main chloride secretory unit in the gastrointestinal tract, we have investigated the effect of 2 8 2 6 bradykinin on acid secretion in the isolated frog (Rana catesbeiana) gastric mucosa. Bradykinin (2 3 10 to 2 3 10 M) and 9 2 9 2 7 des-Arg -bradykinin (2 3 10 to 23 10 M) were able to stimulate acid secretion in a dose-dependent manner. The bradykinin 2 79 2 85,872 7 (2 3 10 M) and des-Arg -bradykinin (2 3 10 M)-induced acid secretion was unaffected by Thi ,D -Phe -bradykinin (2 3 10 to 2 5 98 2 7 2 3 10 M), a B -kinin receptor antagonist. Interestingly, the B -kinin receptor antagonist, des-Arg -(Leu )-bradykinin (2 3 10 to 21 2 59 2 3 10 M) blocked both bradykinin- and des-Arg -bradykinin-stimulated acid secretion. Although the kininase I inhibitor, D -L -2 6 2 59 mercapto-methyl-3-guanidino-ethyl-propanoic acid (23 10 and 23 10 M) had no effect on des-Arg -bradykinin-induced acid 9 secretion, it inhibited the response to bradykinin. We conclude that bradykinin requires, at least in part, hydrolysis to des-Arg –bradykinin to increase gastric acid secretion and that its effect is mediated by B -kinin receptors.
ISSN: 01670115
metadata.dc.rights.license: O periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285361278983.
Appears in Collections:DECBI - Artigos publicados em periódicos

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