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Title: Calcium signaling and sugar-induced activation of plasma membrane H+-ATPase in Saccharomyces cerevisiae cells.
Authors: Trópia, Maria José Magalhães
Cardoso, Anamaria de Souza
Tisi, Renata
Fietto, Luciano Gomes
Fietto, Juliana Lopes Rangel
Martegani, Enzo
Castro, Ieso de Miranda
Brandão, Rogélio Lopes
Keywords: Calcium signaling
Sugar-induced activation
Plasma membrane ATPase
Issue Date: 2006
Citation: TRÓPIA, M. J. M. et al. Calcium signaling and sugar-induced activation of plasma membrane H+-ATPase in Saccharomyces cerevisiae cells. Biochemical and Biophysical Research Communications, v. 343, n. 4, p. 1234-1243, maio 2006. Disponível em: <>. Acesso em: 18 jul. 2012.
Abstract: In this work, we show that glucose-induced activation of plasma membrane H+-ATPase from Saccharomyces cerevisiae is strongly dependent on calcium metabolism and that the glucose sensor Snf3p works in a parallel way with the G protein Gpa2p in the control of the pathway. The role of Snf3p is played by the Snf3p C-terminal tail, since in a strain with the deletion of the SNF3 gene, but also expressing a chimera protein formed by Hxt1p (a glucose transporter) and the Snf3p C-terminal tail, a normal glucose-activation process can be observed. We present evidences indicating that Snf3p would be the sensor for the internal signal (phosphorylated sugars) of this pathway that would connect calcium signaling and activation of the plasma membrane ATPase. We also show that Snf3p could be involved in the control of Pmc1p activity that would regulate the calcium availability in the cytosol.
ISSN: 0006291X
metadata.dc.rights.license: O periódico Biochemical and Biophysical Research Communications concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3266011110500.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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