Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11509
Title: Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment.
Authors: Nhavene, Egídio Paulo Francisco
Silva, Wellington Marcos da
Trivelato Junior, Roberto Reis
Gastelois, Pedro Lana
Venâncio, Tiago
Nascimento, Regiane
Batista, Ronaldo Junio Campos
Machado, Carlos Renato
Macedo, Waldemar Augusto de Almeida
Sousa, Edésia Martins Barros de
Keywords: Surface functionalization
Benznidazol delivery
Issue Date: 2018
Citation: NHAVANE, E. P. F. et al. Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment. Microporous and Mesoporous Materials, v. 272, p. 265-275, dez. 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1387181118303457>. Acesso em: 19 mar. 2019.
Abstract: The use of chitosan functionalized silica for benznidazole delivery in the treatment of neglected disease such as Chagas disease is one of the forms not yet explored, but with great potential for this therapy, as little is known about nanoformulations for the treatment of Chagas disease. In this work, we used chitosan-succinate covalently attached to the surface pore of MSNs to act as anchor for benznidazole as a delivery system. The samples were characterized structurally and chemically with multiple techniques. The applicability of functionalized MSNs as platforms for benznidazole delivery into T. cruzi parasites was assessed. The results demonstrate that the proposed system is a potential promising nanoplatform for drug and gene delivery targeting neglected diseases such as Chagas disease.
URI: http://www.repositorio.ufop.br/handle/123456789/11509
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S1387181118303457
metadata.dc.identifier.doi: https://doi.org/10.1016/j.micromeso.2018.06.035
ISSN: 1387-1811
Appears in Collections:DEFIS - Artigos publicados em periódicos

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