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|Title:||Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study.|
|Authors:||Magalhães, Felipe Lima|
Machado, Alexei Manso Corrêa
Paulino Junior, Eduardo
Sahoo, Sangram K.
Paula, Ana Maria de
Garcia, Aloísio Miguel
Soares, Jaqueline dos Santos
Lewer, Marcelo Henrique Mamede
|Citation:||MAGALHÃES, F. L. et al. Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study. Journal of Biomedical Optics, v. 23, n. 12, p. 121613, 2018. Disponível em: <https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-12/121613/Raman-spectroscopy-with-a-1064-nm-wavelength-laser-as-a/10.1117/1.JBO.23.12.121613.full?SSO=1>. Acesso em: 19 mar. 2019.|
|Abstract:||Raman spectroscopy is widely used to investigate the structure and property of the molecules from their vibrational transitions and may allow for the diagnosis of cancer in a fast, objective, and nondestructive manner. This experimental study aims to propose the use of the 1064-nm wavelength laser in a Raman spectroscopy and to evaluate its discrimination capability in prostate cancer diagnosis. Seventy-four spectra from patients who underwent radical prostatectomy were evaluated. The acquired signals were filtered, normalized, and corrected for possible oscillations in the laser intensity and fluorescence effects. Wilcoxon tests revealed significant differences between the benign and malign samples associated with the deformation vibration characteristic of nucleic acids, proteins, and lipids. A classifier based on support vector machines was able to predict the Gleason scores of the samples with 95% of accuracy, opening a perspective for the use of the 1064-nm excitatory wavelength in prostatic cancer diagnosis.|
|Appears in Collections:||DEFIS - Artigos publicados em periódicos|
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