Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11230
Title: Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis.
Authors: Vegas, Legna Andreina Colina
Godinho, Joseane Lima Prado
Coutinho, Thallita
Correa, Rodrigo de Souza
Souza, Wanderley de
Rodrigues, Juliany Cola Fernandes
Batista, Alzir Azevedo
Navarro Acosta, Maribel Coromoto
Issue Date: 2019
Citation: VEGAS, L. A. C. et al. Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis. New Journal of Chemistry, v. 43, p. 1431-1439, 2019. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2019/nj/c8nj04657c#!divAbstract>. Acesso em: 7 mar. 2019.
Abstract: Four new organoruthenium complexes with formula [RuCl(η6-p-cymene)(μ-FCZ)]2[Cl]2 (1), [RuCl(FCZ)(η6-p-cymene)(PPh3)]PF6 (2), [RuCl(CTZ)(η6-p-cymene)(PPh3)]PF6 (3) and [RuCl(KTZ)(η6-p-cymene)(PPh3)]PF6 (4) (where FCZ: 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)-2-propanol, CTZ: 1-[(2-chlorophenyl)-diphenylmethyl-1H-imidazole] and KTZ: cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine) were synthesized, characterized and evaluated as potential inhibitors for Leishmania amazonensis growth by widely reported methods. Complexes 3 and 4 displayed effective IC50 activities against Leishmania amazonensis promastigotes and intracellular amastigotes in the range of nanomolar concentration. Scanning and transmission electron microscopy analysis of Leishmania amazonensis promastigotes after treatment with 300 or 500 nM of complexes 3 and 4 for 48 h showed morphological alterations in the cell surface, a shortening of the flagellum, loss of mitochondrial matrix, disorganization of the kDNA and abnormal chromatin condensation. Thus, our strategy of incorporating a ruthenium atom into the structure of clinical drugs to improve their efficacy continues to demonstrate suitability for metallodrug discovery purposes.
URI: http://www.repositorio.ufop.br/handle/123456789/11230
metadata.dc.identifier.uri2: https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C8NJ04657C#!divAbstract
metadata.dc.identifier.doi: http://doi.org/10.1039/c8nj04657c
ISSN: 1369-9261
Appears in Collections:DEQUI - Artigos publicados em periódicos

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