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http://www.repositorio.ufop.br/jspui/handle/123456789/11226| Title: | Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells. |
| Authors: | Correa, Rodrigo de Souza Freire, Vitória Barbosa, Marília Imaculada Frazão Bezerra, Daniel Pereira Bomfim, Larissa Mendes Moreira, Diogo Rodrigo de Magalhães Soares, Milena Botelho Pereira Ellena, Javier Alcides Batista, Alzir Azevedo |
| Issue Date: | 2018 |
| Citation: | CORREA, R. de S. et al. Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells. New Journal of Chemistry, v. 42, p. 6794--6802, 2018. Disponível em: <https://pubs.rsc.org/en/content/articlelanding/2018/nj/c7nj04368f#!divAbstract>. Acesso em: 7 mar. 2019. |
| Abstract: | Herein, we used thymine (HThy) as a ligand to form two new ruthenium(II) complexes with formula [Ru(PPh3)2(Thy)(bipy)]PF6 (1) and [Ru(Thy)(bipy)(dppb)]PF6 (2). The complexes were characterized by spectroscopic, spectrometric and X-ray crystallography analyses. Complexes 1 and 2 can interact with ctDNA presenting binding constants, Kb, of 0.4 and 1.2 × 103 M−1, respectively. Their cytotoxic activities towards tumor cell lines (B16-F10, HepG2, K562 and HL-60) and non-tumor cells (PBMCs) were evaluated using the Alamar blue assay. Complex 1 exhibits high cytotoxicity against tumor cells, showing IC50 values of 0.01 and 1.81 μM against the HL-60 and HepG2 cell lines, respectively. Therefore, compound 1 can be considered as a promising antitumor metallodrug. |
| URI: | http://www.repositorio.ufop.br/handle/123456789/11226 |
| metadata.dc.identifier.uri2: | https://pubs.rsc.org/en/content/articlelanding/2018/NJ/C7NJ04368F#!divAbstract |
| metadata.dc.identifier.doi: | http://doi.org/10.1039/c7nj04368f |
| ISSN: | 1369-9261 |
| Appears in Collections: | DEQUI - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_RuThyminateComplexes.pdf Restricted Access | 2,01 MB | Adobe PDF | View/Open |
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