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Título: | Eccentric overload muscle damage is attenuated by a novel angiotensin- (1-7) treatment. |
Autor(es): | Oliveira, Lenice Kappes Becker Totou, Nádia Lúcia Moura, Samara Silva de Kangussu, Lucas Miranda Sinisterra Millán, Ruben Dario Santos, Maria Jose Campagnole dos Coelho, Daniel Barbosa Santos, Daisy Motta Santos, Robson Augusto Souza dos |
Palavras-chave: | Physical performance Muscular damage |
Data do documento: | 2018 |
Referência: | OLIVEIRA, L. K. B. et al. Eccentric overload muscle damage is attenuated by a novel angiotensin- (1-7) treatment. International Journal of Sports Medicine, v. 39, n. 10, p. 743-748, 2018. Disponível em: <https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0633-8892>. Acesso em: 20 fev. 2019. |
Resumo: | The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46± 0.64 vs. placebo 3.80± 0.77 cm) and 24h after exercise (3.07±0.71 vs. 3.73±0.58cm placebo) and higher MS at 24h (24±12N) and 48h (30±15N) vs. placebo (-8 ± 9 N and -10 ± 9 N). The CK for Ang-(1-7) (0.5 ± 0.1 and 0.9±0.2 U/L) were lower at 48 and 72h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38 ± 2.5 pg/ml) vs. placebo (45 ± 2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise. |
URI: | http://www.repositorio.ufop.br/handle/123456789/11126 |
Link para o artigo: | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0633-8892 |
ISSN: | 0172-4622 |
Aparece nas coleções: | DEEFD - Artigos publicados em periódicos |
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ARTIGO_EccentricOverloadMuscle.pdf Restricted Access | 446,69 kB | Adobe PDF | Visualizar/Abrir |
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