Please use this identifier to cite or link to this item:
Title: Eccentric overload muscle damage is attenuated by a novel angiotensin- (1-7) treatment.
Authors: Oliveira, Lenice Kappes Becker
Totou, Nádia Lúcia
Moura, Samara Silva de
Kangussu, Lucas Miranda
Millán, Ruben Dario Sinisterra
Santos, Maria Jose Campagnole dos
Coelho, Daniel Barbosa
Santos, Daisy Motta
Santos, Robson Augusto Souza dos
Keywords: Physical performance
Muscular damage
Issue Date: 2018
Citation: OLIVEIRA, L. K. B. et al. Eccentric overload muscle damage is attenuated by a novel angiotensin- (1-7) treatment. International Journal of Sports Medicine, v. 39, n. 10, p. 743-748, 2018. Disponível em: <>. Acesso em: 20 fev. 2019.
Abstract: The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46± 0.64 vs. placebo 3.80± 0.77 cm) and 24h after exercise (3.07±0.71 vs. 3.73±0.58cm placebo) and higher MS at 24h (24±12N) and 48h (30±15N) vs. placebo (-8 ± 9 N and -10 ± 9 N). The CK for Ang-(1-7) (0.5 ± 0.1 and 0.9±0.2 U/L) were lower at 48 and 72h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38 ± 2.5 pg/ml) vs. placebo (45 ± 2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.
ISSN: 0172-4622
Appears in Collections:DEEFD - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_EccentricOverloadMuscle.pdf446,69 kBAdobe PDFView/Open    Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.