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http://www.repositorio.ufop.br/jspui/handle/123456789/11058
Título : | Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates. |
Autor : | Guilherme, Fernanda Dias Simonetti, Julia Évelin Folquitto, Laís Regina dos Santos Reis, Adriana Cotta Cardoso Oliver, Josidel Conceição Dias, Amanda Latercia Tranches Dias, Danielle Ferreira Carvalho, Diogo Teixeira Brandão, Geraldo Célio Souza, Thiago Belarmino de |
Palabras clave : | Glycosides |
Fecha de publicación : | 2019 |
Citación : | GUILHERME, F. D. et al. Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates. Journal of Molecular Structure, v. 1184, p. 349-356, maio 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0022286019301759>. Acesso em: 25 fev. 2019. |
Resumen : | A new series of glycosylated acylhydrazones was synthesized and all the chemical structures were confirmed by High Resolution Mass Spectrometry (HRMS), 1 H and 13C Nuclear Magnetic Resonance (1 HNMR; 13C-NMR) and Fourier Transform Infrared (FTIR) spectroscopy methods. The mass accuracy between the calculated and found values observed in HRMS analyses were near or lower than 5 ppm, which are acceptable for proposing a molecular formula using this technique. All of the synthesized compounds were screened for their antibacterial, antifungal and antiviral activities. Five compounds (12, 13, 14, 16 and 19) exerted a modest antifungal activity against the strains evaluated. Derivative 14 showed fungicidal activity against Candida glabrata at 173.8 mM and saccharide unit contributed to the increase of the antifungal potential against this strain. New chemical manipulation of derivative 14 can make it possible to obtain new potentially antimicrobial agents. |
URI : | http://www.repositorio.ufop.br/handle/123456789/11058 |
metadata.dc.identifier.uri2: | https://www.sciencedirect.com/science/article/pii/S0022286019301759 |
ISSN : | 0022-2860 |
Aparece en las colecciones: | DEFAR - Artigos publicados em periódicos |
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Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_SynthesisChemicalCharacterization.pdf Restricted Access | 589,88 kB | Adobe PDF | Visualizar/Abrir |
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