Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11058
Title: Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates.
Authors: Guilherme, Fernanda Dias
Simonetti, Julia Évelin
Folquitto, Laís Regina dos Santos
Reis, Adriana Cotta Cardoso
Oliver, Josidel Conceição
Dias, Amanda Latercia Tranches
Dias, Danielle Ferreira
Carvalho, Diogo Teixeira
Brandão, Geraldo Célio
Souza, Thiago Belarmino de
Keywords: Glycosides
Issue Date: 2019
Citation: GUILHERME, F. D. et al. Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates. Journal of Molecular Structure, v. 1184, p. 349-356, maio 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0022286019301759>. Acesso em: 25 fev. 2019.
Abstract: A new series of glycosylated acylhydrazones was synthesized and all the chemical structures were confirmed by High Resolution Mass Spectrometry (HRMS), 1 H and 13C Nuclear Magnetic Resonance (1 HNMR; 13C-NMR) and Fourier Transform Infrared (FTIR) spectroscopy methods. The mass accuracy between the calculated and found values observed in HRMS analyses were near or lower than 5 ppm, which are acceptable for proposing a molecular formula using this technique. All of the synthesized compounds were screened for their antibacterial, antifungal and antiviral activities. Five compounds (12, 13, 14, 16 and 19) exerted a modest antifungal activity against the strains evaluated. Derivative 14 showed fungicidal activity against Candida glabrata at 173.8 mM and saccharide unit contributed to the increase of the antifungal potential against this strain. New chemical manipulation of derivative 14 can make it possible to obtain new potentially antimicrobial agents.
URI: http://www.repositorio.ufop.br/handle/123456789/11058
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S0022286019301759
ISSN: 0022-2860
Appears in Collections:DEFAR - Artigos publicados em periódicos

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