Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/1105
Title: Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
Authors: Cangussu, Luiza Michelle
Castro, Uberdan Guilherme Mendes de
Machado, Raquel do Pilar
Silva, Marcelo Eustáquio
Ferreira, Patrícia Maria
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
Keywords: Caudal ventrolateral medulla
Baroreflex control of heart rate
Angiotensin II
Issue Date: 2009
Citation: CANGUSSU, L. M. et al. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, v. 30, n. 10, p. 1921-1927, out. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978109002666>. Acesso em: 12 jul. 2012.
Abstract: In the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as observed in Sham rats. In both Sham and 2K1C, the hypotensive effect of Ang II and Ang-(1-7) at the CVLM was blocked, for up to 30 min, by previous CVLM microinjection of the Ang II AT 1 receptor antagonist, Losartan, and Ang-(1-7) Mas antagonist, A-779, respectively. As expected, the baroreflex bradycardia was lower in 2K1C in comparison to Sham rats. CVLM microinjection of A-779 improved the sensitivity of baroreflex bradycardia in 2K1C hypertensive rats. In contrast, Losartan had no effect on the baroreflex bradycardia in either 2K1C or Sham rats. These results suggest that Ang-(1-7) at the CVLM may contribute to the low sensitivity of the baroreflex control of heart rate in renovascular hypertensive rats
URI: http://www.repositorio.ufop.br/handle/123456789/1105
ISSN: 01969781
metadata.dc.rights.license: O periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285361083380.
Appears in Collections:DECBI - Artigos publicados em periódicos

Files in This Item:
File SizeFormat 
ARTIGO_AngiotensinAntagonistMicroinjection.pdf569,58 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.