Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11019
Title: Phytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa.
Authors: Gontijo, Douglas da Costa
Diaz, Marisa Alves Nogueira
Brandão, Geraldo Célio
Gontijo, Pablo da Costa
Oliveira, Alaide Braga de
Fietto, Luciano Gomes
Leite, João Paulo Viana
Keywords: Phenolic compounds
lchornea glandulosa
DNA damage
Antioxidant and Antibacterial Action
Issue Date: 2018
Citation: GONTIJO, D. da C. et al. Phytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa. Journal of Toxicology and Environmental Health, Part A Current Issues, v. 81, n. 6, p. 2-14, 2018. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/15287394.2018.1492479?journalCode=uteh20>. Acesso em: 25 fev. 2019.
Abstract: Plant extracts exist as a complex matrix which serves as a source of numerous bioactive metabolites. The ultra performance liquid chromatography with diode-array detection-coupled electrospray ionization-mass spectrometry/mass spectrometry technique was used to characterize the aqueous extract from leaves of Alchornea glandulosa (EAG), a species popularly used to treat gastrointestinal problems as an antiulcer agent. Quantification of phenolic derivatives was determined using Folin–Ciocalteu and aluminum trichloride (AlCl3) methods. In addition, antioxidant (2,2-diphenyl-1-picrylhydrazyl [DPPH• ] radical scavenging, β-carotene–linoleic acid, and lipid peroxidation), antibacterial (agar well diffusion method and minimum inhibitory concentration), antimutagenic (Ames test), and antigenotoxic (plasmid cleavage) assays were also performed on this plant extract. The ellagitannin tris-galloyl-hexahydroxydiphenic acid-glucose was identified as the predominant compound along with tannins as majority metabolites. EAG showed high antioxidant activity accompanied by moderate antibacterial activity against Staphylococcus aureus. The highest antimutagenic activity was observed for TA97 strain without metabolic activation (S9) and with metabolic activation, TA100 and TA102 were completely inhibited. In addition, EAG exhibited potential signs of antigenotoxic action. The high antioxidant and antimutagenic activity observed for EAG suggests important therapeutic uses that still need to be verified in future studies.
URI: http://www.repositorio.ufop.br/handle/123456789/11019
metadata.dc.identifier.uri2: https://www.tandfonline.com/doi/full/10.1080/15287394.2018.1492479
ISSN: 10872620
Appears in Collections:DEFAR - Artigos publicados em periódicos

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