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Title: Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation.
Authors: Ferraz Filha, Zilma Schimith
Ferrari, Fernanda Cristina
Araújo, Marcela Carolina de Paula Michel
Bernardes, Ana Catharina Fernandes Pereira Ferreira
Guimarães, Dênia Antunes Saúde
Issue Date: 2017
Citation: FERRAZ FILHA, Z. S. et al. Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 1-11, 2017. Disponível em: <>. Acesso em: 25 fev. 2019.
Abstract: Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.
ISSN: 17414288
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo
Appears in Collections:DEFAR - Artigos publicados em periódicos

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