Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11013
Title: Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice.
Authors: Souza, Ana Carolina Moreira
Mosqueira, Vanessa Carla Furtado
Silveira, Ana Paula Amariz
Antunes, Lidiane Rodrigues
Richard, Sylvain
Guimarães, Homero Nogueira
Guimarães, Andrea Grabe
Keywords: Electrocardiogram
Malaria
QT interval
Issue Date: 2018
Citation: SOUZA, A. C. M. et al. Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice. Parasitology, v. 145, n. 8, p. 1075-1083, jul. 2018. Disponível em: <https://www.cambridge.org/core/journals/parasitology/article/reduced-cardiotoxicity-and-increased-oral-efficacy-of-artemether-polymeric-nanocapsules-in-plasmodium-bergheiinfected-mice/6932F5098D21304208C64C96DF709932>. Acesso em: 25 fev. 2019.
Abstract: Artemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria. The purposes of this work were to study free-ATM and ATM-loaded poly-ε-caprolactone nanocapules (ATM-NC) cardiotoxicity and oral efficacy on Plasmodium berghei-infected mice. ATM-NC was obtained by interfacial polymer deposition and ATM was associated with polymeric NC oily core. For cardiotoxicity evaluation, male black C57BL6 uninfected or P. berghei-infected mice received, by oral route twice daily/4 days, vehicle (sorbitol/carboxymethylcellulose), blank-NC, free-ATM or ATMNC at doses 40, 80 or 120 mg kg−1 . Electrocardiogram (ECG) lead II signal was obtained before and after treatment. For ATM efficacy evaluation, female P. berghei-infected mice were treated the same way. ATM-NC improved antimalarial in vivo efficacy and reduced mice mortality. Free-ATM induced significantly QT and QTc intervals prolongation. ATMNC (120 mg kg−1 ) given to uninfected mice reduced QT and QTc intervals prolongation 34 and 30%, respectively, compared with free-ATM. ATM-NC given to infected mice also reduced QT and QTc intervals prolongation, 28 and 27%, respectively. For the first time, the study showed a nanocarrier reducing cardiotoxicity of ATM given by oral route and it was more effective against P. berghei than free-ATM as monotherapy.
URI: http://www.repositorio.ufop.br/handle/123456789/11013
metadata.dc.identifier.uri2: https://www.cambridge.org/core/journals/parasitology/article/reduced-cardiotoxicity-and-increased-oral-efficacy-of-artemether-polymeric-nanocapsules-in-plasmodium-bergheiinfected-mice/6932F5098D21304208C64C96DF709932
ISSN: 14698161
Appears in Collections:DEFAR - Artigos publicados em periódicos

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