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dc.contributor.authorBarbosa, Maria Andréa-
dc.contributor.authorCota, Renata Guerra de Sá-
dc.contributor.authorCastro, Uberdan Guilherme Mendes de-
dc.contributor.authorLima, Wanderson Geraldo de-
dc.contributor.authorSantos, Robson Augusto Souza dos-
dc.contributor.authorSantos, Maria José Campagnole dos-
dc.contributor.authorAlzamora, Andréia Carvalho-
dc.identifier.citationBARBOSA, M. A. et al. Physical training improves thermogenesis and insulin pathway, and induces remodeling in white and brown adipose tissues. Journal of Physiology and Biochemistry, v. 74, n. 3, p. 441–454, ago. 2018. Disponível em: <>. Acesso em: 25 fev. 2019.pt_BR
dc.description.abstractPhysical training (PT) has been considered as a treatment in metabolic syndrome (MS), since it induces thermogenic activity in brown (BAT) and white (WAT) adipose tissues. We evaluated the therapeutic effect of PT on activity of WAT and BAT in rats with MS induced by high-fat diet (30% lard) for 13 weeks and submitted, for the last 6 weeks, to swimming or kept sedentary (SED) rats. MS-SED rats compared to control diet (CT-SED) rats showed low physical fitness and high levels of glucose, insulin, homeostasis evaluation of insulin resistance (HOMA-IR), homeostasis evaluation of the functional capacity of β-cells (HOMA-β), and blood pressure. The gastrocnemius muscle decreased in peroxisome proliferator-activated receptor gamma coactivator 1-alpha and beta (PGC-1α, PGC-1β), and uncoupled protein 2 and 3 (UCP2 and UCP3) expressions. Both WAT and BAT increased in the adipocyte area and decreased in blood vessels and fibroblast numbers. WAT increased in expression of pro-inflammatory adipokines and decreased in anti-inflammatory adipokine and adiponectin. WAT and gastrocnemius showed impairment in the insulin signaling pathway. In response to PT, MS rats showed increased physical fitness and restoration of certain biometric and biochemical parameters and blood pressure. PT also induced thermogenic modulations in skeletal muscle, WAT and BAT, and also improved the insulin signaling pathway. Collectively, PT was effective in treating MS by inducing improvement in physical fitness and interchangeable effects between skeletal muscle, WAT and BAT, suggesting a development of brown-like adipocyte cells.pt_BR
dc.subjectHigh-fat dietpt_BR
dc.subjectMetabolic syndromept_BR
dc.subjectAdiposetissue remodelingpt_BR
dc.subjectInsulin signaling pathwaypt_BR
dc.titlePhysical training improves thermogenesis and insulin pathway, and induces remodeling in white and brown adipose tissues.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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