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Title: | A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania amazonensis infection. |
Authors: | Tavares, Grasiele de Sousa Vieira Mendonça, Débora Vasconcelos Costa Miyazaki, Carolina Kei Lage, Daniela Pagliara Soyer, Tauane Gonçalves Carvalho, Lívia Mendes Ottoni, Flaviano Melo Dias, Daniel Silva Ribeiro, Patrícia Aparecida Fernandes Antinarelli, Luciana Maria Ribeiro Ribeiro, Fernanda Ludolf Duarte, Mariana Costa Coimbra, Elaine Soares Chávez Fumagalli, Miguel Angel Roatt, Bruno Mendes Souza, Daniel Menezes Barichello, José Mario Alves, Ricardo José Coelho, Eduardo Antônio Ferraz |
Keywords: | Visceral leishmaniasis 5-chloro-7-iodoquinolin-8-ol Toxicity Delivery systems |
Issue Date: | 2019 |
Citation: | TAVARES, G. de S. V. et al. A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania amazonensis infection. Parasitology International, v. 68, n. 1, p. 63-72, fev. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1383576918303751?via%3Dihub>. Acesso em: 22 fev. 2019. |
Abstract: | Clioquinol (5-chloro-7-iodoquinolin-8-ol or ICHQ) was recently showed to presents an in vitro effective antileishmanial action, causing changes in membrane permeability, mitochondrial functionality, and parasite morphology. In the present study, ICHQ was incorporated into a Poloxamer 407-based polymeric micelles system (ICHQ/M), and its antileishmanial activity was in vivo evaluated in L. amazonensis-infected BALB/c mice. Amphotericin B (AmpB) and its liposomal formulation (Ambisome®) were used as controls. Parasitological and immunological evaluations were performed 30 days after the treatment. Results indicated more significant reductions in the average lesion diameter and parasite burden in ICHQ or ICHQ/M-treated mice, which were associated with the development of a polarized Th1 immune response, based on production of high levels of IFN-γ, IL-12, TNF-α, GM-CSF, and antileishmanial IgG2a antibody. Control groups´ mice produced high levels of IL-4, IL-10, and IgG1 isotype antibody. No organic toxicity was found by using ICHQ or ICHQ/M to treat the animals, although those receiving AmpB and Ambisome® have presented higher levels of renal and hepatic damage markers. In conclusion, results suggested that the ICHQ/M composition can be considered as an antileishmanial candidate to be tested against human leishmaniasis. |
URI: | http://www.repositorio.ufop.br/handle/123456789/10928 |
metadata.dc.identifier.uri2: | https://www.sciencedirect.com/science/article/pii/S1383576918303751 |
ISSN: | 13835769 |
Appears in Collections: | DECBI - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_PluronicF127Based.pdf Restricted Access | 1,7 MB | Adobe PDF | View/Open |
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