Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/10928
Title: A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania amazonensis infection.
Authors: Tavares, Grasiele de Sousa Vieira
Mendonça, Débora Vasconcelos Costa
Miyazaki, Carolina Kei
Lage, Daniela Pagliara
Soyer, Tauane Gonçalves
Carvalho, Lívia Mendes
Ottoni, Flaviano Melo
Dias, Daniel Silva
Ribeiro, Patrícia Aparecida Fernandes
Antinarelli, Luciana Maria Ribeiro
Ribeiro, Fernanda Ludolf
Duarte, Mariana Costa
Coimbra, Elaine Soares
Chávez Fumagalli, Miguel Angel
Roatt, Bruno Mendes
Souza, Daniel Menezes
Barichello, José Mario
Alves, Ricardo José
Coelho, Eduardo Antônio Ferraz
Keywords: Visceral leishmaniasis
5-chloro-7-iodoquinolin-8-ol
Toxicity
Delivery systems
Issue Date: 2019
Citation: TAVARES, G. de S. V. et al. A Pluronic® F127-based polymeric micelle system containing an antileishmanial molecule is immunotherapeutic and effective in the treatment against Leishmania amazonensis infection. Parasitology International, v. 68, n. 1, p. 63-72, fev. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1383576918303751?via%3Dihub>. Acesso em: 22 fev. 2019.
Abstract: Clioquinol (5-chloro-7-iodoquinolin-8-ol or ICHQ) was recently showed to presents an in vitro effective antileishmanial action, causing changes in membrane permeability, mitochondrial functionality, and parasite morphology. In the present study, ICHQ was incorporated into a Poloxamer 407-based polymeric micelles system (ICHQ/M), and its antileishmanial activity was in vivo evaluated in L. amazonensis-infected BALB/c mice. Amphotericin B (AmpB) and its liposomal formulation (Ambisome®) were used as controls. Parasitological and immunological evaluations were performed 30 days after the treatment. Results indicated more significant reductions in the average lesion diameter and parasite burden in ICHQ or ICHQ/M-treated mice, which were associated with the development of a polarized Th1 immune response, based on production of high levels of IFN-γ, IL-12, TNF-α, GM-CSF, and antileishmanial IgG2a antibody. Control groups´ mice produced high levels of IL-4, IL-10, and IgG1 isotype antibody. No organic toxicity was found by using ICHQ or ICHQ/M to treat the animals, although those receiving AmpB and Ambisome® have presented higher levels of renal and hepatic damage markers. In conclusion, results suggested that the ICHQ/M composition can be considered as an antileishmanial candidate to be tested against human leishmaniasis.
URI: http://www.repositorio.ufop.br/handle/123456789/10928
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S1383576918303751
ISSN: 13835769
Appears in Collections:DECBI - Artigos publicados em periódicos

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