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Title: Apolipoprotein e polymorphism in Brazilian dyslipidemic individuals : Ouro Preto study.
Authors: Lana, Angelo Mendes
Pena, Geórgia das Graças
Freitas, Silvia Nascimento de
Lima, Angélica Alves
Nicolato, Roney Luiz de Carvalho
Nascimento Neto, Raimundo Marques do
Coelho, George Luiz Lins Machado
Freitas, Renata Nascimento de
Keywords: Brazilian population
Apolipoprotein E polymorphism
Issue Date: 2007
Citation: LANA, A. M. et al. Apolipoprotein e polymorphism in Brazilian dyslipidemic individuals : Ouro Preto study. Brazilian Journal of Medical and Biological Research, v. 40, n. 1, p. 49-56, jan. 2007. Disponível em: <>. Acesso em: 12 jul. 2012.
Abstract: The influence of apolipoprotein E alleles and genotypes on plasma lipid levels was determined in 185 individuals of mixed ethnicity living in Ouro Preto, Brazil. DNA was obtained from blood samples and the genotypes were determined by an RFLP-PCR procedure. The *3 allele was the most frequent (72%), followed by *4 (20%) and *2 (8%); *4 frequency was higher and *2 frequency was lower in the dyslipidemic group than in the normal control group. The *2 carriers presented lower LDL and total cholesterol levels compared to the *3 and *4 carriers. All six expected genotypes were observed in the individuals genotyped: E2/2 (2.1%), E4/4 (2.7%), E2/4 (3.7%), E2/3 (8.0%), E3/3 (53.3%), E3/4 (29.9%); no difference in genotype frequencies was found between the normal and dyslipidemic groups. Compared with *2, the presence of *3 increases more than two times the risk for dyslipidemia (OR = 2.31; P = 0.025; 95% CI = 1.06-5.06) and the presence of *4 increases it three times (OR = 3.31; P = 0.006; 95% CI = 1.36-8.04). The only significant effect of genotype was an increased risk for dyslipidemia in the *4 genotype carriers (E3/4 + E4/ 4) compared with the *2 genotype carriers (E2/2 + E2/3) with OR = 3.69 (95% CI = 1.25-10.88). The present study indicates that in the Ouro Preto admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.
ISSN: 1414431X
metadata.dc.rights.license: No permission is required from the authors or the publishers to download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. Fonte: Brazilian Journal of Medical and Biological Research <>. Acesso em: 21 jan. 2014.
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