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Title: Peptide vaccines for leishmaniasis.
Authors: Brito, Rory Cristiane Fortes de
Cardoso, Jamille Mirelle de Oliveira
Reis, Levi Eduardo Soares
Vieira, João Filipe Pereira
Mathias, Fernando Augusto Siqueira
Roatt, Bruno Mendes
Soares, Rodrigo Dian de Oliveira Aguiar
Ruiz, Jeronimo Conceição
Resende, Daniela de Melo
Reis, Alexandre Barbosa
Keywords: Tegumentary leishmaniases
Peptide-based vaccines
Chimeric vaccine
Visceral leishmaniasis
Polypeptide vaccines
Issue Date: 2018
Citation: BRITO, R. C. F. de et al. Peptide vaccines for leishmaniasis. Frontiers in Immunology, v. 9, p. 1043, maio 2018. Disponível em: <>. Acesso em: 20 fev. 2019.
Abstract: Due to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits. Nevertheless, the use of whole parasite or their subunits for vaccine production has numerous disadvantages. Therefore, the use of Leishmania peptides to design more specific vaccines against leishmaniases seems promising. Moreover, peptides have several benefits in comparison with other kinds of antigens, for instance, good stability, absence of potentially damaging materials, antigen low complexity, and low-cost to scale up. By contrast, peptides are poor immunogenic alone, and they need to be delivered correctly. In this context, several approaches described in this review are useful to solve these drawbacks. Approaches, such as, peptides in combination with potent adjuvants, cellular vaccinations, adenovirus, polyepitopes, or DNA vaccines have been used to develop peptide-based vaccines. Recent advancements in peptide vaccine design, chimeric, or polypeptide vaccines and nanovaccines based on particles attached or formulated with antigenic components or peptides have been increasingly employed to drive a specific immune response. In this review, we briefly summarize the old, current, and future stands on peptide-based vaccines, describing the disadvantages and benefits associated with them. We also propose possible approaches to overcome the related weaknesses of synthetic vaccines and suggest future guidelines for their development.
ISSN: 16634365
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o próprio artigo
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