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Título: | Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
Autor(es): | Reis, Alexandre Barbosa Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Carvalho, Maria das Graças Mayrink, Wilson Silva, João Carlos França da Giunchetti, Rodolfo Cordeiro Genaro, Odair Oliveira, Rodrigo Corrêa de |
Palavras-chave: | Canine visceral leishmaniasis Leishmania infantum Parasite density Biochemical/hematological status |
Data do documento: | 2006 |
Referência: | REIS, A. B. et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Research in veterinary Science, v. 81, n. 1, p. 68-75, ago. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528805001748>. Acesso em: 10 jul. 2012. |
Resumo: | We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations. |
URI: | http://www.repositorio.ufop.br/handle/123456789/1043 |
ISSN: | 00345288 |
Licença: | O periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410100627. |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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