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Title: | Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs. |
Authors: | Giunchetti, Rodolfo Cordeiro Oliveira, Rodrigo Corrêa de Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Souza, Juliana Vitoriano de Moreira, Nádia das Dores Malaquias, Luiz Cosme Cotta Castro, Luciana Lisboa Mota e Lana, Marta de Reis, Alexandre Barbosa |
Keywords: | Canine visceral leishmaniasis Saponin adjuvant Celland humoral immune response |
Issue Date: | 2007 |
Citation: | GIUNCHETTI, R. C. et al. Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs. Vaccine, v. 25, n. 44, p. 7674-7686, nov. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0264410X07009255>. Acesso em: 10 jul. 2012. |
Abstract: | Cellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti- Leishmania IgG isotypes, together with higher levels of lymphocytes, particularly of circulating CD8 + T-lymphocytes and Leishmania chagasi antigen-specific CD8 + T-lymphocytes. As indicated by the intense cell proliferation and increased nitric oxide production during in vitro stimulation by L. chagasisoluble antigens, the candidate vaccine elicited an immune activation status potentially compatible with effective control of the etiological agent of CVL. |
URI: | http://www.repositorio.ufop.br/handle/123456789/1039 |
ISSN: | 0264410X |
metadata.dc.rights.license: | O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410072386. |
Appears in Collections: | DEACL - Artigos publicados em periódicos |
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ARTIGO_ImmunogenicityKilledLeishmania.pdf | 982,93 kB | Adobe PDF | View/Open |
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