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Title: Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide.
Authors: Soriano, Javier Ramos
Carmen de la Fuente, M.
Cruz, Noelia de la
Figueiredo, Rute Cunha
Rojo Marcos, Francisco Javier
Reina, José Juan
Issue Date: 2017
Citation: SORIANO, J. R. et al. Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide. Organic & Biomolecular Chemistry, v. 2017, n. 15, p. 8878-8882, 2017. Disponível em: <!divAbstract>. Acesso em: 05 abr. 2018.
Abstract: The high-mannose oligosaccharide (or its corresponding Man9 epitope) is the most abundant structure present in pathogen envelope glycoproteins. These glycans play a key role in the pathogenesis of several pathogens and also in the communication with the immune system. Understanding the mechanism of action of these glycans requires the access to pure and chemically well-defined structures in reasonable amounts. The synthesis of these complex branched oligosaccharides is not trivial and few syntheses are reported in the literature with several synthetic and purification steps and low overall yields. In this work, we described a very efficient synthetic alternative to access this relevant Man9 epitope in a very straightforward manner.
ISSN: 14770539
Appears in Collections:DEQUI - Artigos publicados em periódicos

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