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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Carneiro, Cláudia Martins | - |
dc.contributor.author | Martins Filho, Olindo Assis | - |
dc.contributor.author | Reis, Alexandre Barbosa | - |
dc.contributor.author | Veloso, Vanja Maria | - |
dc.contributor.author | Araújo, Flávio Marcos Gomes de | - |
dc.contributor.author | Bahia, Maria Terezinha | - |
dc.contributor.author | Lana, Marta de | - |
dc.contributor.author | Coelho, George Luiz Lins Machado | - |
dc.contributor.author | Gazzinelli, Giovanni | - |
dc.contributor.author | Oliveira, Rodrigo Corrêa de | - |
dc.contributor.author | Tafuri, Wagner Luiz | - |
dc.date.accessioned | 2012-07-10T14:08:49Z | - |
dc.date.available | 2012-07-10T14:08:49Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | CARNEIRO, C. M. et al. Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. Acta Tropica, v. 101, n. 2, p. 120-129, fev. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X07000046>. Acesso em: 10 jul. 2012. | pt_BR |
dc.identifier.issn | 0001706X | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/1036 | - |
dc.description.abstract | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reduction | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.subject | Dog | pt_BR |
dc.subject | Blood (BT) and metacycling (MT) trypomastigotes | pt_BR |
dc.subject | Trypanosoma cruzi | pt_BR |
dc.subject | Flow cytometry | pt_BR |
dc.title | Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | O periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506. | - |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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