Navegando por Autor "Sousa, Rafaela F. de"
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Item Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits : chemical and biological assays.(2020) Pinto, Isabelle Cristina; Seibert, Janaína Brandão; Pinto, Luciano Silva; Santos, Vagner Rodrigues; Sousa, Rafaela F. de; Sousa, Lucas Resende Dutra; Amparo, Tatiane Roquete; Santos, Viviane Martins Rebello dos; Nascimento, Andréa Mendes do; Souza, Gustavo Henrique Bianco de; Vasconcellos, Walison Arthuso; Vieira, Paula Melo de Abreu; Andrade, Ângela LeãoPlants may contain benefcial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total refectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identifed by UPLC–QTOF–MS/MS. The release profle of favonoids and the mechanical properties of the GIC-BPE composite were assessed. The favonoids were released through a linear mechanism governing the difusion for the frst 48 h, as evidenced by the Mt √ /M∞ relatively to t, at a difusion coefcient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not difer signifcantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fbroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.