Navegando por Autor "Simon, Alice"
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Item Development of a novel nano-biomaterial for biomedical applications.(2018) Machado, Vagner de Oliveira; Andrade, Ângela Leão; Simon, Alice; Fernández, Daniel Ernesto Rodríguez; Fabris, José Domingos; Domingues, Rosana Zacarias; Silva, Raphael Ferreira da; Silva, Thamiris Caroline Esteves; Peixoto, Thainá Lopes; Santos, Cláudio Teodoro dos; Motta, Adriana Cristina; Duek, Eliana Aparecida de Rezende; Silva, Messias Borges; Gomes, Alaelson Vieira; Cabral, Lúcio Mendes; Carmo, Flávia Almada do; Elias, Carlos NelsonThe technological development of biodegradable nanoparticles for drug delivery in medical diagnostics and therapies is addressing increasing efforts to make safer, affordable and more bio-efficient polymeric materials. The preparation via the solvent displacement method of a novel polymeric nanomaterial with new spherical and narrow sizes dispersion is described. It was achieved by choosing the best amount of PLDLA-co-TMC, PEO-PPO-PEO and an adequate acetone:methanol volume ratio, using the factorial design 23 and Box-Behnken experiment design. This new material was loaded with finasteride, the chosen drug model, and its delivery dynamic was determined by the HPLC method. Results revealed that an optimal formulation of PLDLA-co-TMC nanoparticles was found to be composed of 20 mg PLDLA-co-TMC; 37.5 mg PEO-PPO-PEO and a volume acetone:methanol ratio 2.2:0.3. The formulation of this novel biomaterial showed a high encapsulation efficiency of finasteride, controlled release profile along 24 h, without burst effect in the first 4 h, nanometric sizes, spherical shapes, close polydispersity, negative surface charge, unimodal particle size distribution and relatively high thermal stability of the polymer matrix PEO-PPO-PEO/PLDLA-co-TMC. These results support the fabrication of technologically advanced nanoparticles based on high molecular weight PLDLA-co-TMC and their use in the nano-controlled drug release in biomedical applications.Item Preparation of hybrid nanocomposite particles for medical practices.(2021) Machado, Vagner de Oliveira; Andrade, Ângela Leão; Fabris, José Domingos; Freitas, Erico Tadeu Fraga; Ferreira, José Maria da Fonte; Simon, Alice; Domingues, Rosana Zacarias; Fernandez Outon, Luis Eugenio; Carmo, Flávia Almada do; Souza, Antônio Carlos dos Santos; Cardoso, Hugo Saba PereiraThis study addresses the preparation of hybrid nanoparticles comprised of magnetite (Fe3O4) cores and a surface functionalized with tetramethylammonium hydroxide (TMAOH). The stabilized core nanoparticles were subse quently coated with a polymer matrix consisting of poly(L-co-D,L lactic acid-co-trimethylene carbonate) and poly (ethylene oxide) − poly(propylene oxide) − poly(ethylene oxide) triblock copolymer. The novel core/shell hybrid nanoparticles combine the concepts of electromagnetic heating by the magnetite cores with the drug storage and release ability of the polymeric shell. These multifunctional hybrid nanoparticles are intended for hyperthermia clinical protocols in local drug delivery and medical practices in oncology. The essential physical features of these hybrid composite nanoparticles were assessed using an array of appropriate advanced char acterization techniques. The equivalent average diameters of the composite nanoparticles were relatively uni form and their core/shell mass ratio was estimated through thermogravimetric analysis. The weakening of the intermolecular interactions with decreasing thickness of the coating led to a concomitant decrease in the melting temperature of the shell. The polydispersity index data from dynamic light scattering analysis enabled the conclusion that polymeric species contained in 10 mL of the polymeric matrix solution could effectively coat a maximum of core particles contained in 0.5 mL of ferrofluid.