Navegando por Autor "Oliveira, Maysa do Vale"
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Item Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis.(2012) Silva, Luciano Bruno Carvalho; Oliveira, Maysa do Vale; Gontijo, Vanessa Silva; Oliveira, Williana Fernandes de; Derogis, Priscilla Bento Matos Cruz; Stringheta, Paulo César; Nagem, Tanus Jorge; Brigagão, Maísa Ribeiro Pereira Lima; Santos, Marcelo Henrique dosThis paper describes the investigation of the cytotoxic and antioxidant activities and in vivo mutagenic/ antimutagenic potential of different concentrations of the hexane extract (EHP) and isolated molecule 7-epi-clusianone (MI) of Rheedia brasiliensis. The in vitro antioxidant activity of MI was investigated by monitoring the reduction of radical scavenging and metal chelating activity of DPPH (1,1-diphenyl-2-picrylhydrazil). Cytotoxic activity was assessed by measuring the mortality of brine shrimp in the presence and absence of the compounds. The mutagenic, antimutagenic and cytotoxic effects of these compounds were evaluated by a micronucleus test. During the antioxidant activity assessment, the 7-epi-clusianone was significantly higher than that of EHP at all concentrations in three assays. From the results obtained with the assessment of cytotoxic activity, all samples had a mortality rate (LC50b100 mg/mL) lower than the positive control (thymol). The results of the micronucleus test revealed that MI at 5, 10 and 15 mg/kg b.w. is antimutagenic. In conclusion, these results suggest that in the future, the EHP and MI could be used as prophylactic agents in cancer prevention.Item Knowledge about cleaning and maintenance of household water reservoirs in one of the oldest municipalities of Brazil.(2020) Nunes, Luiz Gustavo de Paiva; Oliveira, Maysa do Vale; Souza, Anelise Andrade de; Lopes, Lohanna de Farias; Dias, Pollyanna Castro e Silva; Nogueira, Guilherme Bicalho; Souza, Marco Antônio Andrade deMuch of the population does not have access to treated and piped water in the world, and the users themselves are responsible for its harvesting and storage, collecting from any available source, frequently without treatment, or any kind of protection against contamination. Considering that water can be contaminated during storage in the household reservoir, this study sought to evaluate the knowledge of the population about the maintenance of water reservoirs in São Mateus, one of the oldest cities in Brazil, located in the state of Espírito Santo. The information was collected through an interview with residents of 22 districts of the municipality. It was observed that all interviewees were aware of the need to clean the water tank. However, in 14.29% (n=10) of the households, cleaning was not performed. Regarding the cleaning period of the water tank, 61.43% (n=43) of the residents stated that six months was the correct period for cleaning, with 55.71% (n=39) of the residents effectively performing the cleaning in that period. The obtained data show that the knowledge of the population about the correct maintenance of household reservoirs is still unsatisfactory. This leads to a decrease in the quality of stored water and increases the spread of waterborne diseases.