Implications of oxidative stress on viral pathogenesis.
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2016
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Reactive species are frequently formed after
viral infections. Antioxidant defences, including enzymatic
and non-enzymatic components, protect against reactive
species, but sometimes these defences are not completely
adequate. An imbalance in the production of reactive
species and the body’s inability to detoxify these reactive
species is referred to as oxidative stress. The aim of this
review is to analyse the role of oxidative stress in the
pathogenesis of viral infections and highlight some major
therapeutic approaches that have gained importance, with
regards to controlling virus-induced oxidative injury.
Attention will be focused on DNA viruses (papillomaviruses,
hepadnaviruses), RNA viruses (flaviviruses,
orthomyxoviruses, paramyxoviruses, togaviruses) and
retroviruses (human immunodeficiency virus). In general,
viruses cause an imbalance in the cellular redox environment,
which depending on the virus and the cell can result
in different responses, e.g. cell signaling, antioxidant
defences, reactive species, and other processes. Therefore,
the modulation of reactive species production and oxidative
stress potentially represents a novel pharmacological
approach for reducing the consequences of viral
pathogenesis.
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CAMINI, F. C. et al. Implications of oxidative stress on viral pathogenesis. Archives of Virology, v. 30, p. 1, 2016. Disponível em: <https://link.springer.com/article/10.1007/s00705-016-3187-y>. Acesso em: 15 set. 2017.