The entrance route : oral, mucous, cutaneous, or systemic has a marked influence on the outcome of Trypanosoma cruzi experimental infection.
Nenhuma Miniatura disponível
Data
2022
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
In recent decades, the oral infection of Trypanosoma cruzi has gathered increased attention due to frequent
outbreaks that can lead to more severe clinical signs than those usually found in the areas of vector transmission.
This study addresses the main routes of infection using metacyclic trypomastigotes (MT) and blood trypomastigotes (BT). Herein, BALB/c mice were infected with the Colombian (TcI) strain via intraperitoneal (IP), oral,
intragastric (IG), ocular (OC) and cutaneous (CT) routes with 106 culture-derived MT or BT. Parasitemia was
intermittent and low in animals inoculated with MT, in contrast, high parasitemia levels were found in BT-mice.
A tropism for the muscles was observed in oral or IG infection with BT. Differently, the parasite was widely
distributed in the tissues of mice infected with MT. However, the intensity of the inflammation infiltrating the
tissues was higher in oral or IG infection with BT. Animals inoculated with BT via the IG route had similar serum
levels of IFN-γ and smaller IL-10 compared to those infected with MT via the IG route. TNF-α levels were higher
in the serum from BT-animals, which could explain the higher intensity of heart inflammation in these animals.
Our results suggest that the infective form and the route of infection differentially modulated the outcome of
Trypanosoma cruzi mice infection.
Descrição
Palavras-chave
Trypanosoma cruzi, Oral Chagas disease, Metacyclic trypomastigote, Blood trypomastigote, Acute chagas disease
Citação
GONÇALVES, K. R. et al. The entrance route: oral, mucous, cutaneous, or systemic has a marked influence on the outcome of Trypanosoma cruzi experimental infection. Acta Tropica, v. 233, artigo 106581, out. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X2200273X>. Acesso em: 01 ago. 2023.