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dc.contributor.authorVital, Wendel Coura-
dc.contributor.authorCarneiro, Cláudia Martins-
dc.contributor.authorMartins, Helen Rodrigues-
dc.contributor.authorLana, Marta de-
dc.contributor.authorVeloso, Vanja Maria-
dc.contributor.authorCarvalho, Andréa Teixeira de-
dc.contributor.authorBahia, Maria Terezinha-
dc.contributor.authorOliveira, Rodrigo Corrêa de-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.contributor.authorTafuri, Wagner Luiz-
dc.contributor.authorReis, Alexandre Barbosa-
dc.identifier.citationVITAL, W. C. et al. Trypanosoma cruzi : immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes. Experimental Parasitology, v. 120, n. 3, p. 269-274, nov. 2008. Disponível em: <>. Acesso em: 05 jul. 2012pt_BR
dc.description.abstractA detailed investigation has been carried out about the serological profiles of groups of dogs experimen-tally infected with metacyclic (MT) or blood (BT) trypomastigotes of Berenice-78 Trypanosoma cruzi strain. Peripheral blood was collected from infected dogs and uninfected controls, weekly during 35 days following the acute phase of infection, and immunoglobulin profiles were determined by ELISA. Dogs infected with BT exhibited unaltered levels of IgG2, increases in IgM, IgE, IgA, IgG and IgG1. In contrast, dogs infected with MT presented unaltered levels of IgE and IgG1 and an increase in IgM, IgA, IgG and IgG2 levels. Compared with the MT group, animals infected with BT showed significant increases in IgM on days 7, 14 and 28, in IgA on days 7, 14 and 21, in IgE on days 7 and 14, in IgG on days 14 and 28, and in IgG1 on days 7, 14 and 21. Parasitemia levels of the infected animals were measured over the same time period. No correlations were found between the immunoglobulin profiles and the parasi-temia levels. The results demonstrated that the inoculum source (BT or MT) influence the immunoglob-ulin isotype profile that may drive distinct outcome of acute canine Chagas diseasept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectChagas' diseasept_BR
dc.subjectCanine modelpt_BR
dc.subjectClass and subclass of immunoglobulinspt_BR
dc.titleTrypanosoma cruzi : immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990771185.-
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