HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.
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2010
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Background Earlier, a G/T single nucleotide polymorphism (SNP) in the HMGCR gene was shown to significantly reduce
the overall serum lipids response to pravastatin. This study aimed to investigate the relationship of the rs17238540 SNP
with coronary heart disease, stroke and cardiovascular disease risk.
Design Cross-sectional study from the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort.
Methods Genotype was determined by pyrosequencing 23 011 participants, for whom clinical and biochemical data were
available. Baseline risk factors according to genotype were evaluated, and the risk for fatal and nonfatal stroke, ischaemic
heart disease and all types of cardiovascular diseases were assessed by logistic regression after approximately 11 years of
follow-up.
Results The G allele carriers presented 1.4 mmHg higher systolic blood pressure and 0.8 mmHg higher diastolic blood
pressure than those who were TT carriers. They also presented higher risk of prevalent total (odds ratio: 1.44, 95%
confidence interval: 1.05–1.97, P = 0.025) and nonfatal (odds ratio: 1.56, 95% confidence interval: 1.12–2.17, P = 0.009) stroke
events compared with the TT individuals in the multivariate models.
Conclusion An association between the rs17238540 SNP and stroke risk was observed, independent of the effect of the
SNP on the blood pressure. The possible mechanisms involved, besides the effect on blood pressure, might be related to
pleiotropic functions of the HMGCR, and remain to be explored.
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FREITAS, R. N. de et al. HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study. European Journal of Cardiovascular Prevention & Rehabilitation, v. 17, p. 89-93, 2010. Disponível em: <https://journals.sagepub.com/doi/10.1097/HJR.0b013e328330be77>. Acesso em: 21 mar. 2017.