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http://www.repositorio.ufop.br/jspui/handle/123456789/8125
Título: | TNFR1 absence protects against memory deficit induced by sepsis possibly through. |
Autor(es): | Calsavara, Allan Jefferson Cruz Soriani, Frederico Marianetti Vieira, Leda Quercia Costa, Priscila de Almeida Rachid, Milene Alvarenga Teixeira Junior, Antonio Lucio |
Palavras-chave: | Sepsis Memory impairment |
Data do documento: | 2014 |
Referência: | CALSAVARA, A. J. C. et al. TNFR1 absence protects against memory deficit induced by sepsis possibly through. Metabolic Brain Disease, v.30, p. 669–678, 2014. Disponível em:<https://link.springer.com/article/10.1007%2Fs11011-014-9610-8> . Acesso em: 16 jun. 2017. |
Resumo: | The involvement of TNF-α type 1 receptor (TNFR1) in memory deficits induced by sepsis was explored by using TNFR1 knockout (KO) mice. We reported that wild type (WT) mice presented memory deficits in the novel object recognition test 10 days after sepsis induced by cecumligation and perforation (CLP). These deficits were not observed in TNFR1 KO mice. The involvement of serum and brain cytokines TNF-α, IL-1β, IL-6, IFN-γ and IL-10 was then investigated. TNFR1 KO mice had higher serum levels of TNF-α and IL-1β, and brain levels of TNF-α than WT mice. After CLP, the brain levels of TNF-α, IL-1β, IL-6 and IFN-γ increased in both WT and KO mice. Our next step was to determine the expression of inflammatory cytokines, BDNF and TrKb in the hippocampus. The absence of TNFR1 inmice subjected to polymicrobial sepsis resulted in higher BDNF expression in the hippocampus. In conclusion, after CLP, memory is preserved in the absence of TNFR1. This finding was associated with increased BDNF expression in the hippocampus. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8125 |
Link para o artigo: | https://link.springer.com/article/10.1007%2Fs11011-014-9610-8 |
DOI: | https://doi.org/10.1007/s11011-014-9610-8 |
ISSN: | 1573-7365 |
Aparece nas coleções: | DECPA - Artigos publicados em periódicos |
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ARTIGO_TNFR1AbsenceProtects.pdf Restricted Access | 752,93 kB | Adobe PDF | Visualizar/Abrir |
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