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Título : | 2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities. |
Autor : | Doriguetto, Antônio Carlos Martins, Felipe Terra Ellena, Javier Alcides Salloum, Rogério Santos, Marcelo Henrique dos Moreira, Maria Eliza de Castro Silva, Jose Mauricio Schneedorf Ferreira da Nagem, Tanus Jorge |
Fecha de publicación : | 2007 |
Citación : | DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017. |
Resumen : | The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed. |
URI : | http://www.repositorio.ufop.br/handle/123456789/7982 |
metadata.dc.identifier.uri2: | http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract |
metadata.dc.identifier.doi: | https://doi.org/10.1002/cbdv.200790041 |
ISSN : | 1612-1880 |
Aparece en las colecciones: | DEQUI - Artigos publicados em periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_TrihydroxybenzopheneCrystalStructure.pdf Restricted Access | 348,36 kB | Adobe PDF | Visualizar/Abrir |
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