Please use this identifier to cite or link to this item:
http://www.repositorio.ufop.br/jspui/handle/123456789/7982
Title: | 2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities. |
Authors: | Doriguetto, Antônio Carlos Martins, Felipe Terra Ellena, Javier Alcides Salloum, Rogério Santos, Marcelo Henrique dos Moreira, Maria Eliza de Castro Silva, Jose Mauricio Schneedorf Ferreira da Nagem, Tanus Jorge |
Issue Date: | 2007 |
Citation: | DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017. |
Abstract: | The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7982 |
metadata.dc.identifier.uri2: | http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract |
metadata.dc.identifier.doi: | https://doi.org/10.1002/cbdv.200790041 |
ISSN: | 1612-1880 |
Appears in Collections: | DEQUI - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ARTIGO_TrihydroxybenzopheneCrystalStructure.pdf Restricted Access | 348,36 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.