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Title: Leishmania chagasi : effect of the iron deficiency on the infection in BALB/c mice.
Authors: Malafaia, Guilherme
Marcon, Letícia de Nadai
Pereira, Liliane de Fátima
Pedrosa, Maria Lúcia
Rezende, Simone Aparecida
Keywords: Visceral leishmaniasis
Issue Date: 2011
Citation: MALAFAIA, G. et al. Leishmania chagasi: effect of the iron deficiency on the infection in BALB/c mice. Experimental Parasitology, v. 127, p. 719-723, 2011. Disponível em: <>. Acesso em: 20 jan. 2017.
Abstract: Iron deficiency and visceral leishmaniasis are serious problems of public health. The aim of this study was to evaluate the effect of iron deficiency, induced by the iron chelator desferrioxamine, on the course of the infection by Leishmania chagasi in BALB/c mice. Our data show that the iron chelator caused significant reduction in hemoglobin concentration of treated mice and reduction in parasite load in spleen and liver. Significant differences were not observed in the production of IFN-gamma and IL-4 among the experimental groups. In conclusion, the data reported in this paper suggest that iron deficiency may favor the host. If there is not enough iron available to the parasite, its multiplication may be reduced and infection attenuated.
ISSN: 0014-4894
Appears in Collections:DEFAR - Artigos publicados em periódicos

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